The Science Behind eeze
The research behind our ingredients. Every eeze ingredient earns its place — here is the published, peer-reviewed science behind the fruits, fibers, and minerals in Daily-eeze and Travel-eeze, with every study linked so you can explore it yourself. The research below looks at each ingredient — the building blocks we thoughtfully formulate with.
Jerusalem artichoke inulin
In Daily-eeze ›Inulin is a soluble prebiotic fiber — food for the beneficial bacteria that already live in your gut. Daily-eeze uses organic inulin from Jerusalem artichoke root, one of nature's richest sources. In a double-blind, placebo-controlled trial of 66 healthy adults, Jerusalem artichoke inulin significantly raised levels of beneficial Bifidobacteria compared with placebo — and those levels returned to baseline once supplementation stopped, showing the fiber itself was doing the work.[1]
A 2025 systematic review and meta-analysis of fiber trials reached the same conclusion on the microbiome: prebiotic fibers like inulin significantly increased fecal Bifidobacteria and reduced reliance on laxatives.[2]
And in a separate randomized, placebo-controlled trial, chicory inulin significantly improved stool frequency in adults with constipation — without causing digestive discomfort.[13]
From the research: Jerusalem artichoke inulin produced significantly higher gut Bifidobacteria than placebo in a randomized controlled trial (P < 0.0001).[1]
↑ Higher is better
Relative gut Bifidobacteria in the trial — the inulin group reached about 5× the level of placebo (log-scale data shown as fold-difference). More is better.[1]
Flaxseed
In Travel-eeze ›Flaxseed brings gentle, fiber-based support for regularity. In a clinical study of older adults with chronic constipation, four weeks of flaxseed meaningfully improved constipation symptom scores and increased weekly bowel movements, while shifting the gut microbiome toward beneficial species.[3] It's the kind of steady, food-first fiber that works with your body rather than forcing it.
A randomized trial in a separate population likewise found flaxseed improved functional constipation and quality of life.[14]
From the research: In constipated adults, flaxseed cut Wexner constipation scores roughly in half and raised weekly bowel movements, with an 88% overall response rate.[3]
↓ Lower is better
Constipation symptom score (Wexner) before and after 4 weeks of flaxseed — lower is better. Weekly bowel movements also rose from 3.8 to 6.2.[3]
Raspberry
In Travel-eeze ›Beyond its bright Bora Bora Berry flavor, raspberry is one of the most fiber-dense common fruits — the USDA lists 8 grams of dietary fiber in a single cup.[5] Early laboratory research on colonic fermentation suggests whole raspberry has a prebiotic effect, driven largely by its natural polyphenols and reflected in higher short-chain fatty acid production.[4] This is emerging, preclinical science — promising, and honest about where the evidence stands today.
Did you know? A single cup of raspberries carries about 8 grams of fiber — among the highest of any common fruit.[5]
↑ Higher is better
Dietary fiber per 1-cup serving (USDA FoodData Central). Raspberries are among the most fiber-dense fruits.[5][12]
Elderberry
In Daily-eeze ›Elderberry (Sambucus nigra) is a traditional immune-support botanical with real clinical study behind it. In a randomized, double-blind, placebo-controlled trial of 312 air travelers, elderberry was associated with shorter, less severe colds.[6] A later meta-analysis of randomized trials concluded elderberry "substantially reduce[s] upper respiratory symptoms."[7] We include it in Daily-eeze as part of an everyday immune-supporting blend alongside vitamin C.
A 2021 systematic review of randomized trials concluded elderberry "may be a safe option for treating viral respiratory illness."[15]
From the research: Air travelers taking elderberry recorded roughly half the cold-episode days of the placebo group (57 vs 117).[6]
↓ Lower is better
Total cold-episode days across the study group — fewer is better. Randomized trial of 312 air travelers.[6]
Magnesium
In Travel-eeze ›Magnesium is one of the best-studied minerals for occasional constipation. It works osmotically — drawing water into the intestine to soften stool and support normal muscle relaxation. In a randomized, placebo-controlled trial, magnesium supplementation significantly increased spontaneous bowel movements and softened stool consistency versus placebo.[8] Travel-eeze uses magnesium citrate, a well-absorbed form of this gentle, water-based mineral.
From the research: Magnesium significantly raised spontaneous bowel movements over placebo in a randomized controlled trial (P = 0.002).[8]
↑ Higher is better
Improvement in weekly spontaneous bowel movements over the trial — more is better.[8]
Across two randomized trials summarized in a 2021 review, roughly 70% of people taking magnesium improved, versus about 25% on placebo.[16]
Vitamin C
In Daily-eeze & Travel-eeze ›Vitamin C is a genuine multitasker. The U.S. National Institutes of Health notes it "plays an important role in immune function,"[9] and research shows it concentrates in immune cells and helps defend the body's barriers against pathogens.[17] A Cochrane review of controlled trials found that taking it regularly can shorten colds — and in people under intense physical stress, it cut the risk of catching one nearly in half.[11] Daily-eeze delivers a generous daily dose of vitamin C, while Travel-eeze uses a buffered form — paired with minerals to be gentle on the stomach.
↓ Lower is better
Relative risk of catching a cold in people under intense physical stress (placebo = 100) — vitamin C roughly halved it. With regular daily use it also shortened colds by 8–14%.[11]
Cascara sagrada
In Travel-eeze ›Cascara is a traditional botanical recognized by both the U.S. National Institutes of Health and the European Medicines Agency as a stimulant laxative for occasional constipation.[18][10] Its naturally occurring compounds — called cascarosides — gently stimulate the colon and draw water into the stool to help it pass more easily.[18] We include just a modest amount in Travel-eeze, matched to occasional travel days and routine changes. For everyday, ongoing regularity, Daily-eeze's prebiotic fiber is the daily choice.
How to read this page
The research we cite comes from the most rigorous kinds of studies: randomized controlled trials (the gold standard), systematic reviews and meta-analyses that pool many trials, and authoritative monographs from bodies like the NIH and European Medicines Agency. Where the science is still early — as with raspberry's laboratory-stage prebiotic research — we say so plainly. Nutrition science evolves, and we'd rather show you exactly where things stand than overstate it.
References
- Ramnani P, Gaudier E, Bingham M, van Bruggen P, Tuohy KM, Gibson GR. Prebiotic effect of fruit and vegetable shots containing Jerusalem artichoke inulin: a human intervention study. British Journal of Nutrition. 2010. doi:10.1017/S000711451000036X
- Xi N, Yang X, Liu J, Yue H, Wang Z. Effects of Dietary Fiber Supplementation on Chronic Constipation in the Elderly: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Foods. 2025. doi:10.3390/foods14132315
- Ma J, Sun J, Bai H, et al. Influence of Flax Seeds on the Gut Microbiota of Elderly Patients with Constipation. Journal of Multidisciplinary Healthcare. 2022. doi:10.2147/JMDH.S379708
- Núñez-Gómez V, Periago MJ, Navarro-González I, Campos-Cava MP, Baenas N, González-Barrio R. Influence of Raspberry and Its Dietary Fractions on the In vitro Activity of the Colonic Microbiota from Normal and Overweight Subjects. Plant Foods for Human Nutrition. 2021. doi:10.1007/s11130-021-00923-6
- U.S. Department of Agriculture, SNAP-Ed Connection. Seasonal Produce Guide: Raspberries (8 g dietary fiber per 1-cup serving). snaped.fns.usda.gov
- Tiralongo E, Wee SS, Lea RA. Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial. Nutrients. 2016;8(4):182. doi:10.3390/nu8040182
- Hawkins J, Baker C, Cherry L, Dunne E. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complementary Therapies in Medicine. 2019. doi:10.1016/j.ctim.2018.12.004
- Mori S, Tomita T, Fujimura K, et al. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation. Journal of Neurogastroenterology and Motility. 2019. doi:10.5056/jnm18194
- National Institutes of Health, Office of Dietary Supplements. Vitamin C — Fact Sheet for Health Professionals. ods.od.nih.gov
- European Medicines Agency, Committee on Herbal Medicinal Products. Rhamni purshianae cortex (Cascara). ema.europa.eu
- Hemilä H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database of Systematic Reviews. 2013. doi:10.1002/14651858.CD000980.pub4
- U.S. Department of Agriculture, FoodData Central. Dietary fiber values for fruits (per 1-cup serving). fdc.nal.usda.gov
- Micka A, Siepelmeyer A, Holz A, Theis S, Schön C. Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial. International Journal of Food Sciences and Nutrition. 2017;68(1):82-89. doi:10.1080/09637486.2016.1212819
- Sun J, Bai H, Ma J, et al. Effects of flaxseed supplementation on functional constipation and quality of life in a Chinese population: A randomized trial. 2020. PubMed PMID: 32229443
- Wieland LS, Piechotta V, Feinberg T, et al. Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review. BMC Complementary Medicine and Therapies. 2021;21:112. doi:10.1186/s12906-021-03283-5
- Mori H, Tack J, Suzuki H. Magnesium Oxide in Constipation. Nutrients. 2021;13(2):421. doi:10.3390/nu13020421
- Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017;9(11):1211. doi:10.3390/nu9111211
- National Institutes of Health. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury — Cascara. Bethesda (MD): NIDDK. ncbi.nlm.nih.gov/books/NBK548113
Real ingredients, real research.
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The studies referenced explore individual ingredients — sometimes at amounts different from our blends — and are shared here for educational context. Everyone's body is different, so results naturally vary. If you have a medical condition, are pregnant or nursing, or take medications, we recommend checking with your healthcare provider first.